Drug Dose and Its Concentration at Receptors Essay - 1

Drug Dose and Its Concentration at Receptors - strive ExampleThese factors are discussed in more detail below, based on the description of Goodman, et al. (2011, ch. 2). The characteristics of the drug tittle itself that affect the drugs concentration at the receptor site include its molecular size, floor of ionization, lipid solubility, and its affinity for serum and tissue proteins. The plasma membrane (of skin or intestinal cells, for example) is a common barrier to drug distribution drugs that are non lipid soluble will not be able to permeate the membrane and not reach the target site. A drug of atomic molecular size will travel more easily through with(predicate) the membranes than a larger molecule, stretchability the target in higher concentrations. Ionized molecules, and those that bind to proteins, also have difficulties in passing through the membrane. If the drug has a tendency to ionize at the pH of the intestinal lumen or the blood, the ionised form will have dif ficulty passing through lipid plasma membranes. If the drug interacts with conveyor belt proteins on the cell membrane, its uptake into the cell may be increased or decreased, depending on the mission in which the transporter moves the drug. For example, the P-glycoprotein in enterocytes limits the oral absorption of some cancer chemotherapeutic agents by export them back into the lumen of the GI tract. Similarly, it has been found that multidrug transporters such as P-glycoprotein (PGP) and members of the multidrug resistance-associated protein (MRP) family are over-expressed in capillary endothelial cells in epileptogenic brain tissue, and, by transporting anti-epileptic drugs out, these proteins may be responsible for the pharmacoresistance of the epileptic brain to anti-epileptic drugs (Lscher and Potschka, 2002).